| Date | Holiday | Type | Notes |
|---|---|---|---|
| 01 Jan 2021 | New Year's Day | National | |
| 01 Mar 2021 | Heroes' Day | National | |
| 01 Apr 2021 | Maundy Thursday | National | |
| 02 Apr 2021 | Good Friday | National | |
| 01 May 2021 | Labor Day / May Day | National | |
| 14 May 2021 | National Holiday | National | |
| 15 May 2021 | Independence Day | National | |
| 12 Jun 2021 | Chaco Armistice | National | |
| 15 Aug 2021 | Founding of Asuncion | National | |
| 29 Sep 2021 | Boqueron Battle Victory Day | National | |
| 08 Dec 2021 | Virgin of Caacupé Day | National | |
| 25 Dec 2021 | Christmas Day | National |
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